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Synthesis of Dasatinib and it’s intermediate

Production introduction: Dasatinib has been used in treating with adult patients with drug resistance or untolerant chronic myelogenous leukemia. Recently, Dasatinib also used in treatment of patients with Philadephia chromosome positive acute Lmphocytic Leukemia.
Brief introduction: Starting with ethyl 2- aminothizaole-5-carboxylate, through the ammonia production, ester hydrolysis and condensation get the target product.
The synthesis technology is mature, suitable for use in domestic declaration and the yield is high. It does not involve patents production, easy industrialization, environmental protection, the relevant material conform to the requirements of the domestic new drugs.


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